Reaction Details Report a problem with these data
Target
Hrh3 protein
Ligand
BDBM22914
Substrate
n/a
Ki
6.46±n/a nM
Comments
PDSP_1847
Citation
 Wieland, K; Bongers, G; Yamamoto, Y; Hashimoto, T; Yamatodani, A; Menge, WM; Timmerman, H; Lovenberg, TW; Leurs, R Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists. J Pharmacol Exp Ther 299:908-14 (2001) [PubMed] 
Target
Name:
Hrh3 protein
Synonyms:
HISTAMINE H3 | HRH3 | Hrh3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37860.96
Organism:
RAT
Description:
Q5PPG3
Residue:
344
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDY
  
Inhibitor
Name:
BDBM22914
Synonyms:
CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide | Thioperamide | US11622967, Compound Thioperamide
Type:
Small organic molecule
Emp. Form.:
C15H24N4S
Mol. Mass.:
292.443
SMILES:
S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Structure:
Search PDB for entries with ligand similarity: