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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM163970
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Temperature
277.15±n/a K
Ki
650±n/a nM
Comments
extracted
Citation
 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Substituted 7-azabicycles and their use as orexin receptor modulators US Patent  US9695183 Publication Date 7/4/2017 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R
Type:
Protein
Mol. Mass.:
46817.55
Organism:
Rattus norvegicus (Rat)
Description:
P56718
Residue:
416
Sequence:
MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
  
Inhibitor
Name:
BDBM163970
Synonyms:
US9062078, 101 | US9475819, 101 | US9637496, 101 | US9695183, 101
Type:
Small organic molecule
Emp. Form.:
C22H26FN5O2
Mol. Mass.:
411.4725
SMILES:
Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2 |TLB:20:19:17.16:14|
Structure:
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