Ki Summary

Reaction Details

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Target

Pro-thyrotropin-releasing hormone-B

Ligand

BDBM86214

Substrate

n/a

200±n/a nM

Comments

PDSP_3207

Citation

Lu, X; Bidaud, I; Ladram, A; Gershengorn, MC Pharmacological studies of thyrotropin-releasing hormone (TRH) receptors from Xenopus laevis: is xTRHR3 a TRH receptor? Endocrinology 144:1842-6 (2003) [PubMed] Article

More Info.:

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Target

Name:

Pro-thyrotropin-releasing hormone-B

Synonyms:

TRHB_XENLA | trh-b | thyrotropin-releasing hormone R2

Type:

Enzyme Catalytic Domain

Mol. Mass.:

26145.36

Organism:

clawed frog

Description:

thyrotropin-releasing hormone R2 0 Xenopus::Q00643

Residue:

224

Sequence:

MMFLWWLLLLGTAISHKVHSQEQPLLEEDTAPADNLDVLEKAKGILIRSFLEGFQEGQQINRDLPDAMEMIYKRQHPGKRFQEEIEKRQHPGKRDLEDLQLSKRQHPGRRYLEDMEKRQHPGKREEGDWSRGYLTDDSGYLDLFSDVSKRQHPGKRVPDPFFIKRQHPGKRGIEEEDDTEFENSKEVGKRQHPGKRYDPCEGPNAYNCNSGNLQLDSVEEGWAA

Inhibitor

Name:

BDBM86214

Synonyms:

NSC_32281 | CAS_32281 | TRH | Phe2TRH

Type:

Small organic molecule

Emp. Form.:

n/a

Mol. Mass.:

n/a

SMILES:

NC(=O)C1CCCN1C(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1

Structure: