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Target
Oxysterols receptor LXR-alpha
Ligand
BDBM20176
Substrate
n/a
Ki
250±n/a nM
Comments
PDSP_6977
Citation
 Bramlett, KS; Houck, KA; Borchert, KM; Dowless, MS; Kulanthaivel, P; Zhang, Y; Beyer, TP; Schmidt, R; Thomas, JS; Michael, LF; Barr, R; Montrose, C; Eacho, PI; Cao, G; Burris, TP A natural product ligand of the oxysterol receptor, liver X receptor. J Pharmacol Exp Ther 307:291-6 (2003) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-alpha
Synonyms:
NR1H3_HUMAN | NR1H3 | LXRA | Liver X receptor alpha (NR1H3) | Liver X receptor alpha (LXRA) | Liver X, LXR alpha | Liver X receptor alpha | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 | Liver X Receptor alpha (LXR-alpha)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50403.85
Organism:
Human
Description:
Q13133
Residue:
447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM20176
Synonyms:
(1S,2R,5S,10S,11S,14R,15S)-14-[(2S,3S)-3-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol | 22(R)-hydroxycholesterol | 22(S)-hydroxycholesterol
Type:
Steroid
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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