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Target
Muscarinic acetylcholine receptor M5
Ligand
BDBM86292
Substrate
n/a
Ki
0.51±n/a nM
Comments
PDSP_3131
Citation
 De Amici, M; Conti, P; Fasoli, E; Barocelli, E; Ballabeni, V; Bertoni, S; Impicciatore, M; Roth, BL; Ernsberger, P; De Micheli, C Synthesis and in vitro pharmacology of novel heterocyclic muscarinic ligands. Farmaco 58:739-48 (2003) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M5
Synonyms:
ACM5_HUMAN | CHRM5
Type:
PROTEIN
Mol. Mass.:
60102.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517990
Residue:
532
Sequence:
MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
  
Inhibitor
Name:
BDBM86292
Synonyms:
2-[4-(2-Methyl-1H-imidazol-1-yl)-2-butynyl]isoxazolidin-3-one sesquifumarate | CAS_0 | NSC_0
Type:
Small organic molecule
Emp. Form.:
C11H13N3O2
Mol. Mass.:
219.2398
SMILES:
Cc1nccn1CC#CCN1OCCC1=O
Structure:
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