Reaction Details
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Glycerophosphocholine phosphodiesterase GPCPD1
Ligand
BDBM14776
Substrate
n/a
Ki
2.95±n/a nM
Comments
PDSP_6937
Citation
Teixeira, CE; Priviero, FB; Webb, RC Differential effects of the phosphodiesterase type 5 inhibitors sildenafil, vardenafil, and tadalafil in rat aorta. J Pharmacol Exp Ther 316:654-61 (2006) [PubMed] Article More Info.:
Target
Name:
Glycerophosphocholine phosphodiesterase GPCPD1
Synonyms:
GPCP1_RAT | Gde5 | Gpcpd1 | Phosphodiesterase 5 | Putative glycerophosphocholine phosphodiesterase GPCPD1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
76256.67
Organism:
RAT
Description:
Phosphodiesterase 5 0 RAT::Q80VJ4
Residue:
672
Sequence:
MTPSQVTFEIRGTLLPGEVFAMCGNCDALGNWSPQNAVPLTESETGESVWKAVIVLSRGMSVKYRYFRGCFLEPKTIGGPCQVIVHKWETHLQPRSITPLENEIIIDDGQFGIHNGVETLDSGWLTCQTEIRLRLHFSEKPPVSITKKKFKKSRFRVKLTLEGLEEDDDDDDKASPTVLHKMSNSLEISLISDNEFKCRHSQPECGYGLQPDRWTEYSIQTMEPDNLELIFDFFEEDLSEHVVQGDVLPGHVGTACLLSSTIAESERSAGILTLPIMSRSSRKTIGKVRVDFIIIKPLPGYSCSMQSSFSKYWKPRIPLDVGHRGAGNSTTTAKLAKVQENTIASLRNAASHGAAFVEFDVHLSKDLVPVVYHDLTCCLTMKRKYEADPVELFEIPVKELTFDQLQLLKLSHVTALKTKDQKQCMAEEENSFSENQPFPSLKMVLESLPENVGFNIEIKWICQHRDGVWDGNLSTYFDMNAFLDIILKTVLENSGKRRIVFSSFDADICTMVRQKQNKYPILFLTQGKSDIYPELMDLRSRTTPIAMSFAQFENILGINAHTEDLLRNPSYVQEAKDKGLVIFCWGDDTNDPENRRKLKEFGVNGLIYDRIYDWMPEQPNIFQVEQLERLKRELPELKNCLCPTVSHFIPPSFCMESKIHVDANGIDNVENA
Inhibitor
Name:
BDBM14776
Synonyms:
2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phenyl}-5-methyl-7-propyl-3H,4H-imidazo[1,5-a][1,2,4]triazin-4-one | CHEMBL1520 | Vardenafil | citric acid;2-[2-ethoxy-5-(4-ethylpiperazino)sulfonyl-phenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one
Type:
Small organic molecule
Emp. Form.:
C23H32N6O4S
Mol. Mass.:
488.603
SMILES:
CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1
Structure:
