Reaction Details
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GTP-binding nuclear protein GSP1/CNR1
Ligand
BDBM29094
Substrate
n/a
Ki
7.8±n/a nM
Comments
PDSP_8426
Citation
Wang, H; Duffy, RA; Boykow, GC; Chackalamannil, S; Madison, VS Identification of novel cannabinoid CB1 receptor antagonists by using virtual screening with a pharmacophore model. J Med Chem 51:2439-46 (2008) [PubMed] Article More Info.:
Target
Name:
GTP-binding nuclear protein GSP1/CNR1
Synonyms:
CANNABINOID CB1 | CNR1 | CST17 | GSP1 | GSP1_YEAST | GTP-binding nuclear protein GSP1/CNR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24810.06
Organism:
Saccharomyces cerevisiae
Description:
CANNABINOID CB1 CNR1 0::P32835
Residue:
219
Sequence:
MSAPAANGEVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATIGVEVHPLSFYTNFGEIKFDVWDTAGQEKFGGLRDGYYINAQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLAGNPQLEFVASPALAPPEVQVDEQLMQQYQQEMEQATALPLPDEDDADL
Inhibitor
Name:
BDBM29094
Synonyms:
(+/-)-SLV319 | (S)-3-(4-chlorophenyl)-N-(4-chlorophenylsulfonyl)-N'-methyl-4-phenyl-4,5-dihydropyrazole-1-carboxamidine | 3-(4-chlorophenyl)-N''''-(4-chlorophenylsulfonyl)-N-methyl-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamide | 4-Chloro-N-[1-[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-1-methylamino-meth-(E)-ylidene]-benzenesulfonamide | CHEMBL158784 | SLV-319 | ibipinabant
Type:
Small organic molecule
Emp. Form.:
C23H20Cl2N4O2S
Mol. Mass.:
487.402
SMILES:
CN=C(NS(=O)(=O)c1ccc(Cl)cc1)N1CC(C(=N1)c1ccc(Cl)cc1)c1ccccc1 |w:1.0,c:18|
Structure:
