Reaction Details Report a problem with these data
Target
Zinc finger protein GLI1
Ligand
BDBM77198
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay
IC50
2900±n/a nM
Citation
 PubChem, PC Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Zinc finger protein GLI1
Synonyms:
GLI1_MOUSE | Gli | Gli1 | Glioma-associated oncogene homolog
Type:
PROTEIN
Mol. Mass.:
118579.34
Organism:
Mus musculus
Description:
EBI_101259
Residue:
1111
Sequence:
MFNPMTPPQVNSYSEPCCLRPLHSQGVPSMGTEGLSGLPFCHQANFMSGSQGYGAARETSSCTEGSLFPPPPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPHDSTRGSMMLHPQSRGPRATCQLKSELDMMVGKCPEDPLEGDMSSPNSTGTQDHLLGMLDGREDLEREEKPEPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKREREGGSGREESRLTVPESAMPQQSPGAQSSCSSDHSPAGSAANTDSGVEMAGNAGGSTEDLSSLDEGPCVSATGLSTLRRLENLRLDQLHQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVSLDRRSSSSSSMSSAYTVSRRSSLASPFPPGTPPENGASSLPGLTPAQHYMLRARYASARGSGTPPTAAHSLDRMGGLSVPPWRSRTEYPGYNPNAGVTRRASDPARAADHPAPARVQRFKSLGCVHTPPSVATGRNFDPHHPTSVYSPQPPSITENVAMDTRGLQEEPEVGTSVMGNGLNPYMDFSSTDTLGYGGPEGTAAEPYEARGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPENWGEFPSHAGVYPSNKAPGAAYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGSPGPQPLFSHHPQLPQPQYPQSGPYPQPPHGYLSTEPRLGLNFNPSSSHSTGQLKAQLVCNYVQSQQELLWEGRNRGGLPNQELPYQSPKFLGGSQVSQSPAKTPAAAAAAYGSGFAPASANHKSGSYPAPSPCHETFTVGVNRPSHRPAAPPRLLPPLSPCYGPLKVGDTNPSCGHPEVGRLGAGPALYPPPEGQVCNALDSLDLDNTQLDFVAILDEAQGLSPPLSHEQGDSSKNTPSPSGPPNMAVGNMSVLLGSLPGETQFLNSSA
  
Inhibitor
Name:
BDBM77198
Synonyms:
5,6-dimethyl-4-[4-[2-(4-methylphenoxy)ethyl]-1-piperazinyl]thieno[2,3-d]pyrimidine | 5,6-dimethyl-4-[4-[2-(4-methylphenoxy)ethyl]piperazin-1-yl]thieno[2,3-d]pyrimidine | 5,6-dimethyl-4-[4-[2-(4-methylphenoxy)ethyl]piperazino]thieno[2,3-d]pyrimidine | 5,6-dimethyl-4-{4-[2-(4-methylphenoxy)ethyl]-1-piperazinyl}thieno[2,3-d]pyrimidine | MLS000537743 | SMR000143981 | cid_1999904
Type:
Small organic molecule
Emp. Form.:
C21H26N4OS
Mol. Mass.:
382.522
SMILES:
Cc1sc2ncnc(N3CCN(CCOc4ccc(C)cc4)CC3)c2c1C
Structure:
Search PDB for entries with ligand similarity: