Reaction Details Report a problem with these data
Target
Zinc finger protein GLI1
Ligand
BDBM89300
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay
IC50
2120±n/a nM
Citation
 PubChem, PC Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Zinc finger protein GLI1
Synonyms:
GLI1_MOUSE | Gli | Gli1 | Glioma-associated oncogene homolog
Type:
PROTEIN
Mol. Mass.:
118579.34
Organism:
Mus musculus
Description:
EBI_101259
Residue:
1111
Sequence:
MFNPMTPPQVNSYSEPCCLRPLHSQGVPSMGTEGLSGLPFCHQANFMSGSQGYGAARETSSCTEGSLFPPPPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPHDSTRGSMMLHPQSRGPRATCQLKSELDMMVGKCPEDPLEGDMSSPNSTGTQDHLLGMLDGREDLEREEKPEPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKREREGGSGREESRLTVPESAMPQQSPGAQSSCSSDHSPAGSAANTDSGVEMAGNAGGSTEDLSSLDEGPCVSATGLSTLRRLENLRLDQLHQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVSLDRRSSSSSSMSSAYTVSRRSSLASPFPPGTPPENGASSLPGLTPAQHYMLRARYASARGSGTPPTAAHSLDRMGGLSVPPWRSRTEYPGYNPNAGVTRRASDPARAADHPAPARVQRFKSLGCVHTPPSVATGRNFDPHHPTSVYSPQPPSITENVAMDTRGLQEEPEVGTSVMGNGLNPYMDFSSTDTLGYGGPEGTAAEPYEARGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPENWGEFPSHAGVYPSNKAPGAAYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGSPGPQPLFSHHPQLPQPQYPQSGPYPQPPHGYLSTEPRLGLNFNPSSSHSTGQLKAQLVCNYVQSQQELLWEGRNRGGLPNQELPYQSPKFLGGSQVSQSPAKTPAAAAAAYGSGFAPASANHKSGSYPAPSPCHETFTVGVNRPSHRPAAPPRLLPPLSPCYGPLKVGDTNPSCGHPEVGRLGAGPALYPPPEGQVCNALDSLDLDNTQLDFVAILDEAQGLSPPLSHEQGDSSKNTPSPSGPPNMAVGNMSVLLGSLPGETQFLNSSA
  
Inhibitor
Name:
BDBM89300
Synonyms:
(E)-N-[3-(1-azepanylsulfonyl)-4-methylphenyl]-3-(2-furanyl)-2-propenamide | (E)-N-[3-(azepan-1-ylsulfonyl)-4-methyl-phenyl]-3-(2-furyl)acrylamide | (E)-N-[3-(azepan-1-ylsulfonyl)-4-methyl-phenyl]-3-(furan-2-yl)prop-2-enamide | (E)-N-[3-(azepan-1-ylsulfonyl)-4-methylphenyl]-3-(furan-2-yl)prop-2-enamide | MLS000392992 | SMR000248086 | cid_5885591
Type:
Small organic molecule
Emp. Form.:
C20H24N2O4S
Mol. Mass.:
388.481
SMILES:
Cc1ccc(NC(=O)\C=C\c2ccco2)cc1S(=O)(=O)N1CCCCCC1
Structure:
Search PDB for entries with ligand similarity: