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Target
Acetylcholine-binding protein
Ligand
BDBM50004108
Substrate
n/a
Meas. Tech.
Radioligand Competition Assay
Ki
83±10 nM
Citation
 Rohde, LA; Ahring, PK; Jensen, ML; Nielsen, EØ; Peters, D; Helgstrand, C; Krintel, C; Harpsøe, K; Gajhede, M; Kastrup, JS; Balle, T Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine α4β2 receptors: unique role of halogen bonding revealed. J Biol Chem 287:4248-59 (2012) [PubMed]  Article 
Target
Name:
Acetylcholine-binding protein
Synonyms:
Acetylcholine Binding protein | Acetylcholine-binding protein (Ls-AchBP) | AchBP | Acetylcholine-binding protein (AchBP) | ACh-binding protein | ACHP_LYMST
Type:
n/a
Mol. Mass.:
26055.52
Organism:
Great pond snail
Description:
Soluble acetylcholine receptor
Residue:
229
Sequence:
MRRNIFCLACLWIVQACLSLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTENSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRSEIL
  
Inhibitor
Name:
BDBM50004108
Synonyms:
(R,S)-nicotine | (RS)-nicotine | nicotine | (+-)-nicotine | CHEMBL440464 | Nicotin | US8609708, 54 Nicotine | Nikotin | Nicotine-(+) | 3-(1-methylpyrrolidin-2-yl)pyridine | US9284322, Nicotine | US9993465, Nicotine | US11667638, Example Nicotine
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
C[N@@]1CCC[C@H]1c2cccnc2
Structure:
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