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Target
Acetylcholine-binding protein
Ligand
BDBM50088454
Substrate
n/a
Meas. Tech.
Radioligand Competition Assay
Ki
1.3±0.9 nM
Citation
 Rohde, LA; Ahring, PK; Jensen, ML; Nielsen, EØ; Peters, D; Helgstrand, C; Krintel, C; Harpsøe, K; Gajhede, M; Kastrup, JS; Balle, T Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine α4β2 receptors: unique role of halogen bonding revealed. J Biol Chem 287:4248-59 (2012) [PubMed]  Article 
Target
Name:
Acetylcholine-binding protein
Synonyms:
Acetylcholine Binding protein | Acetylcholine-binding protein (Ls-AchBP) | AchBP | Acetylcholine-binding protein (AchBP) | ACh-binding protein | ACHP_LYMST
Type:
n/a
Mol. Mass.:
26055.52
Organism:
Great pond snail
Description:
Soluble acetylcholine receptor
Residue:
229
Sequence:
MRRNIFCLACLWIVQACLSLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTENSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRSEIL
  
Inhibitor
Name:
BDBM50088454
Synonyms:
NS3920, 4 | CHEMBL306387 | 1-(6-bromopyridin-3-yl)-1,4-diazepane | 1-(6-Bromo-pyridin-3-yl)-[1,4]diazepane
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
c1cc(ncc1N2CCCNCC2)Br
Structure:
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