Reaction Details Report a problem with these data
Target
Beta-adrenergic receptor kinase 1
Ligand
BDBM84342
Substrate
n/a
Meas. Tech.
Inhibition Assay
Kd
610±0.0 nM
Citation
 Strader, CD; Candelore, MR; Hill, WS; Sigal, IS; Dixon, RA Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor. J Biol Chem 264:13572-8 (1989) [PubMed] 
Target
Name:
Beta-adrenergic receptor kinase 1
Synonyms:
ADRBK1 | ARBK1_HUMAN | BARK | BARK1 | Beta-ARK-1 | Beta-adrenergic receptor kinase 1 | G-protein coupled receptor kinase 2 | G-protein coupled receptor kinase 2 (GRK2) | GRK2
Type:
Enzyme
Mol. Mass.:
79581.30
Organism:
Homo sapiens (Human)
Description:
P25098
Residue:
689
Sequence:
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLVQRGSANGL
  
Inhibitor
Name:
BDBM84342
Synonyms:
4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol | 4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol, 1 | 4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol;hydrochloride | 4-[1-hydroxy-2-(methylamino)ethyl]pyrocatechol;hydrochloride | 4-[2-(methylamino)-1-oxidanyl-ethyl]benzene-1,2-diol;hydrochloride | DL-ADRENALINE HYDROCHLORIDE | EPINEPHRINE | EPINEPHRINE,(+) | MLS001333244 | SMR000058236 | cid_5924
Type:
Small organic molecule
Emp. Form.:
C9H13NO3
Mol. Mass.:
183.2044
SMILES:
CNCC(O)c1ccc(O)c(O)c1
Structure:
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