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Target
Aurora kinase A
Ligand
BDBM87053
Substrate
n/a
Meas. Tech.
In Vitro Enzyme Assay
IC50
2.5±0.3 nM
Citation
 Lawrence, HR; Martin, MP; Luo, Y; Pireddu, R; Yang, H; Gevariya, H; Ozcan, S; Zhu, JY; Kendig, R; Rodriguez, M; Elias, R; Cheng, JQ; Sebti, SM; Schonbrunn, E; Lawrence, NJ Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors. J Med Chem 55:7392-416 (2012) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AURKA_HUMAN | AIRK1 | hARK1 | STK15 GN | STK6 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Synonyms=AIK | AURKA | Breast tumor-amplified kinase | STK15 | Serine/threonine kinase 15 | Breast-tumor-amplified kinase | Serine/threonine-protein kinase aurora-A | Aurora kinase A (AURKA) | AYK1 | aurora-2 | AIK | BTAK | ARK-1 | Aurora kinase A (AURA) | ARK1 | Aurora/IPL1-related kinase 1 | Aurora 2 | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora kinase A (Aurora A) | Serine/threonine-protein kinase aurora A | IAK1 | AURA
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Human
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM87053
Synonyms:
Bisanilinopyrimidine, 3l | Bisanilinopyrimidine inhibitor, 7 | US9249124, 13
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
c1ccc(c(c1)Nc2ccnc(n2)Nc3ccc(cc3)C(=O)O)Cl
Structure:
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