Reaction Details Report a problem with these data
Target
Prolyl hydroxylase EGLN2
Ligand
BDBM93420
Substrate
n/a
Meas. Tech.
PHD Enzymatic Assay
IC50
32±n/a nM
Citation
 Murray, JK; Balan, C; Allgeier, AM; Kasparian, A; Viswanadhan, V; Wilde, C; Allen, JR; Yoder, SC; Biddlecome, G; Hungate, RW; Miranda, LP Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1a prolyl hydroxylases-1, -2, and -3 with altered selectivity. J Comb Chem 12:676-86 (2010) [PubMed]  Article 
Target
Name:
Prolyl hydroxylase EGLN2
Synonyms:
EGLN2 | EGLN2_HUMAN | EIT6 | Egl nine homolog 2 | Estrogen-induced tag 6 | HIF prolyl hydroxylase | HIF-PH1 | HIF-prolyl hydroxylase 1 | HPH-3 | Hypoxia-inducible factor prolyl hydroxylase | PHD1 | Prolyl hydroxylase domain-containing protein 1 | Prolyl hydroxylase domain-containing protein 1 (PHD1)
Type:
Protein
Mol. Mass.:
43657.01
Organism:
Homo sapiens (Human)
Description:
Q96KS0
Residue:
407
Sequence:
MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAGSGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRKWAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALDYIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQIAWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDNPHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEVKPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
  
Inhibitor
Name:
BDBM93420
Synonyms:
PHD Inhibitor, 12{3,1,4}
Type:
Small molecule
Emp. Form.:
C38H45N5O8
Mol. Mass.:
699.7926
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)C(C)(C)C)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1 |r|
Structure:
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