Reaction Details Report a problem with these data
Target
Hepatocyte nuclear factor 4-alpha
Ligand
BDBM94597
Substrate
n/a
IC50
>39841±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization PubChem Bioassay (2012)[AID] 
Target
Name:
Hepatocyte nuclear factor 4-alpha
Synonyms:
HNF4 | HNF4A | HNF4A_HUMAN | NR2A1 | TCF14 | hepatocyte nuclear factor 4-alpha isoform b
Type:
PROTEIN
Mol. Mass.:
52790.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_606516
Residue:
474
Sequence:
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
  
Inhibitor
Name:
BDBM94597
Synonyms:
(Z)-2-butenedioate;10-(1-methyl-4-piperidinylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one | (Z)-but-2-enedioate;10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one | 10-(1-methyl-4-piperidylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one;maleate | Ketotifen | Ketotifen fumarate | MLS002222254 | SMR001307257 | US9138431, KETOTIFEN | US9333199, KETOTIFEN | cid_45479747 | cid_5282408
Type:
Small organic molecule
Emp. Form.:
C19H19NOS
Mol. Mass.:
309.425
SMILES:
[#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccsc2-[#6](=O)-[#6]-c2ccccc-12
Structure:
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