Reaction Details Report a problem with these data
Target
Neuromedin-K receptor
Ligand
BDBM242749
Substrate
n/a
Meas. Tech.
Aequorin Assay with Human NK-3 Receptor
IC50
44.0±n/a nM
Citation
 Hoveyda, H; Dutheuil, G; Fraser, G Substituted [1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists US Patent  US10030025 Publication Date 7/24/2018 
Target
Name:
Neuromedin-K receptor
Synonyms:
NK-3 receptor | NK-3R | NK3R | NK3R_HUMAN | NKR | Neurokinin 3 receptor | Neurokinin B receptor | Neurokinin-3 (NK-3) | Neuromedin-3 receptor (NK-3R) | Neuromedin-3 receptor (NK3) | Neuromedin-K receptor | Neuromedin-K receptor (NK-3 receptor) | Neuromedin-K receptor (NK3) | Neuromedin-K receptor(NK3R) | TAC3R | TACR3 | Tachykinin receptor 3 | Tachykinin receptor 3 (NK3)
Type:
Enzyme
Mol. Mass.:
52221.96
Organism:
Homo sapiens (Human)
Description:
P29371
Residue:
465
Sequence:
MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGLPVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADTTRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
  
Inhibitor
Name:
BDBM242749
Synonyms:
US10030025, Compound 13 | US10836768, Cpd no 13 | US11731974, Compound 13 | US9422299, 13 | US9987274, Compound 13
Type:
Small organic molecule
Emp. Form.:
C17H17FN6O2
Mol. Mass.:
356.3543
SMILES:
CCc1noc(n1)-c1nnc2[C@@H](C)N(CCn12)C(=O)c1ccc(F)cc1 |r|
Structure:
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