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Target
Substance-K receptor
Ligand
BDBM242749
Substrate
n/a
Meas. Tech.
Selectivity Assay with Human NK-2
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
>30000±n/a nM
Comments
extracted
Citation
 Hoveyda, H; Dutheuil, G; Fraser, G Substituted [1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists US Patent  US10030025 Publication Date 7/24/2018 
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:
Protein
Mol. Mass.:
44455.78
Organism:
Homo sapiens (Human)
Description:
P21452
Residue:
398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
  
Inhibitor
Name:
BDBM242749
Synonyms:
US10030025, Compound 13 | US10836768, Cpd no 13 | US11731974, Compound 13 | US9422299, 13 | US9987274, Compound 13
Type:
Small organic molecule
Emp. Form.:
C17H17FN6O2
Mol. Mass.:
356.3543
SMILES:
CCc1noc(n1)-c1nnc2[C@@H](C)N(CCn12)C(=O)c1ccc(F)cc1 |r|
Structure:
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