Reaction Details Report a problem with these data
Target
TGF-beta receptor type-1
Ligand
BDBM50262685
Substrate
n/a
IC50
7829±0.0 nM
Citation
 Mohedas, AH; Xing, X; Armstrong, KA; Bullock, AN; Cuny, GD; Yu, PB Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor. ACS Chem Biol 8:1291-302 (2013) [PubMed]  Article 
Target
Name:
TGF-beta receptor type-1
Synonyms:
TGFR-1 | TbetaR-I | ESK2 | TGFR1_MOUSE | Transforming growth factor-beta receptor type I | 2.7.11.30 | ALK5 | Tgfbr1 | TGF-beta receptor type I | AU017197
Type:
n/a
Mol. Mass.:
56186.39
Organism:
Mouse
Description:
n/a
Residue:
503
Sequence:
MEAAAAAPRRPQLLIVLVAAATLLPGAKALQCFCHLCTKDNFTCETDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGAVTTTYCCNQDHCNKIELPTTGPFSEKQSAGLGPVELAAVIAGPVCFVCIALMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM50262685
Synonyms:
CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine | Dorsomorphin | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | US9040694, Dorsomorphin
Type:
Small organic molecule
Emp. Form.:
C24 H25 N5 O
Mol. Mass.:
399.4882
SMILES:
c1cc(ccc1c2cnc3c(cnn3c2)c4ccncc4)OCCN5CCCCC5
Structure:
Search PDB for entries with ligand similarity: