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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM103323
Substrate
n/a
Meas. Tech.
Calcium Mobilization Assay
IC50
229±n/a nM
Citation
 Schwink, L; Stengelin, S; Gossel, M; Wirth, K Substituted indanes, method for the production thereof, and use thereof as drugs US Patent  US8552199 Publication Date 10/8/2013 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM103323
Synonyms:
US8552199, 1-47
Type:
Small organic molecule
Emp. Form.:
C30H38N2O3
Mol. Mass.:
474.6343
SMILES:
CN([C@@H]1Cc2ccc(CN3CC4CCC3CC4)cc2C1)C(=O)c1ccc(OC[C@@H]2CCCO2)cc1 |r,wU:28.31,2.1,TLB:8:9:13.12:15.16,(-.73,-1.59,;-.33,-.1,;1.21,-.1,;2.11,-1.34,;3.58,-.87,;4.91,-1.64,;6.25,-.87,;6.25,.67,;7.58,1.44,;8.91,.67,;9.72,-.75,;11.05,-.77,;11.41,1.24,;10.54,2.38,;10.18,.67,;12.32,-.94,;11.81,-2.48,;4.91,1.44,;3.58,.67,;2.11,1.15,;-1.42,.99,;-1.02,2.48,;-2.91,.59,;-3.31,-.9,;-4.79,-1.29,;-5.88,-.21,;-7.37,-.6,;-8.46,.48,;-9.95,.09,;-10.85,1.33,;-12.32,.86,;-12.32,-.68,;-10.85,-1.16,;-5.48,1.28,;-4,1.68,)|
Structure:
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