Target
Transmembrane prolyl 4-hydroxylase
Ligand
BDBM109268
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
2.6e+2±n/a nM
Citation
 Thede, KFlamme, IOehme, FErgüden, JStoll, FWild, HKolkhof, PBeck, HJeske, M Substituted dipyridyl-dihydropyrazolones and use thereof US Patent  US8609698 Publication Date 12/17/2013 
Target
Name:
Transmembrane prolyl 4-hydroxylase
Synonyms:
Hypoxia-inducible factor prolyl 4-hydroxylase | Hypoxia-inducible factor prolyl hydroxylase | Hypoxia-inducible factor prolyl hydroxylase 4 | Hypoxia-inducible factor prolyl hydroxylase 4 (HIF) | P4HTM | P4HTM_HUMAN | PH4 | Transmembrane prolyl 4-hydroxylase
Type:
Enzyme
Mol. Mass.:
56654.25
Organism:
Homo sapiens (Human)
Description:
Q9NXG6
Residue:
502
Sequence:
MAAAAVTGQRPETAAAEEASRPQWAPPDHCQAQAAAGLGDGEDAPVRPLCKPRGICSRAYFLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVGHERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYEEAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREGGTDSQPEWALDRAYRDARVEL
  
Inhibitor
Name:
BDBM109268
Synonyms:
US8609698, 10
Type:
Small organic molecule
Emp. Form.:
C14H9BrN4O3
Mol. Mass.:
361.15
SMILES:
OC(=O)c1ccc(nc1)-n1[nH]cc(-c2cncc(Br)c2)c1=O
Structure:
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