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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM110712
Substrate
n/a
Meas. Tech.
Pim Kinase Binding Activity
pH
7.2±n/a
Ki
0.003±n/a nM
Comments
extracted
Citation
 Hodges, AJ; Matteucci, M; Sharpe, A; Sun, M; Wang, X; Tsui, VH Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use US Patent  US8614206 Publication Date 12/24/2013 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM110712
Synonyms:
US8614206, 167
Type:
Small organic molecule
Emp. Form.:
C20H23F4N7OS
Mol. Mass.:
485.502
SMILES:
CN=C(C(NC(=O)c1nc(sc1N)-c1c(F)cccc1F)C=N)N1CC[C@@H](N)CC(F)(F)C1 |r,w:1.0|
Structure:
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