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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM113716
Substrate
n/a
Meas. Tech.
Biological Assay
Temperature
298.1500±n/a K
IC50
85±n/a nM
Comments
extracted
Citation
 Zhou, G; Wishart, G; Ting, PC; Aslanian, RG; Zorn, N; Kim, DW Bicyclic compounds as inhibitors of diacylglycerol acyltransferase US Patent  US8637507 Publication Date 1/28/2014 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
Diacylglycerol Acyltransferase (DGAT1) | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | ACAT-related gene product 1 | Diglyceride acyltransferase | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | DGAT1_HUMAN | DGAT1 | AGRP1 | DGAT
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Human
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM113716
Synonyms:
US8637507, C-91
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
OC(=O)C1CCC(CC1)Oc1ccc(cn1)-c1ccc2N(CCOc2c1)C(=O)Nc1ccc(F)cc1C(F)(F)F |(11.34,3.08,;10,2.31,;10,.77,;8.67,3.08,;7.34,2.31,;6,3.08,;6,4.62,;7.34,5.39,;8.67,4.62,;4.67,5.39,;3.33,4.62,;3.33,3.08,;2,2.31,;.67,3.08,;.67,4.62,;2,5.39,;-.67,2.31,;-.67,.77,;-2,,;-3.33,.77,;-4.67,,;-6,.77,;-6,2.31,;-4.67,3.08,;-3.33,2.31,;-2,3.08,;-4.67,-1.54,;-3.33,-2.31,;-6,-2.31,;-7.34,-1.54,;-7.34,,;-8.67,.77,;-10,,;-11.34,.77,;-10,-1.54,;-8.67,-2.31,;-8.67,-3.85,;-8.67,-5.39,;-7.13,-3.85,;-10.21,-3.85,)|
Structure:
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