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Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM50443351
Substrate
n/a
Meas. Tech.
Enzyme Activity Assay
IC50
0.18±n/a nM
Citation
 Shen, D; Debenham, JS; Graham, TH; Clements, MJ; Zhang, Y Prolylcarboxypeptidase inhibitors US Patent  US8669252 Publication Date 3/11/2014 
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
Lysosomal carboxypeptidase C | Angiotensinase C | Proline carboxypeptidase | Prolylcarboxypeptidase | PCP_HUMAN | PRCP | PCP | Prolylcarboxypeptidase (PRCP)
Type:
Enzyme
Mol. Mass.:
55805.19
Organism:
Human
Description:
P42785
Residue:
496
Sequence:
MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH
  
Inhibitor
Name:
BDBM50443351
Synonyms:
CHEMBL3086037 | US8669252, 15
Type:
Small organic molecule
Emp. Form.:
C29H31BrClN3O2
Mol. Mass.:
568.93
SMILES:
Clc1ccc(cc1)C(NC(=O)[C@@H]1CC[C@H](C[C@H]1c1ccc(Br)cc1)N1CCOCC1)c1ccncc1 |r|
Structure:
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