Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM119472
Substrate
n/a
Meas. Tech.
Cell Response Assay
IC50
28±n/a nM
Citation
 Tatani, K; Kawamura, N; Kondo, T; Kondo, A Indole derivative or pharmaceutically acceptable salt thereof US Patent  US8680120 Publication Date 3/25/2014  BDB Entry
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
Prostanoid EP1 receptor
Type:
Enzyme
Mol. Mass.:
43080.10
Organism:
Rattus norvegicus (Rat)
Description:
P70597
Residue:
405
Sequence:
MSPYGLNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLAQVAGRLRRRRSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALALLAAMALAVALLPLVHVGHYELQYPGTWCFISLGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRENAGPDDRRRWGSRGLRLASASSASSITSTTAALRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELSLTKSAWEASSLRSSRHSGFSHL
  
Inhibitor
Name:
BDBM119472
Synonyms:
US8680120, 25-28
Type:
Small organic molecule
Emp. Form.:
C22H16F2N2O3
Mol. Mass.:
394.3708
SMILES:
COc1cc2cc(-c3ccccc3F)n(Cc3cccc(n3)C(O)=O)c2cc1F
Structure:
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