Reaction Details Report a problem with these data
Target
Arginase
Ligand
BDBM50427900
Substrate
n/a
Meas. Tech.
ITC
pH
8.5±0
Kd
2.6e+2± 2e+1 nM
Citation
 Hai, Y; Edwards, JE; Van Zandt, MC; Hoffmann, KF; Christianson, DW Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis Biochemistry 53:4671-4684 (2014) [PubMed]  Article
Target
Name:
Arginase
Synonyms:
Arginase (SmARG)
Type:
Protein
Mol. Mass.:
39912.83
Organism:
Schistosoma mansoni (flatworms)
Description:
Q6WVP6
Residue:
364
Sequence:
MLKSVATPYYPIQDEKPKLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKHTVELSGSKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQTKQ
  
Inhibitor
Name:
BDBM50427900
Synonyms:
(R)-2-amino-6-borono-2-[2-(piperidin-1-yl)ethyl]hexanoic acid (ABH-PE) | CHEMBL2326089
Type:
Small organic molecule
Emp. Form.:
C13H27BN2O4
Mol. Mass.:
286.175
SMILES:
N[C@](CCCCB(O)O)(CCN1CCCCC1)C(O)=O |r|
Structure:
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