Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 5A
Ligand
BDBM135783
Substrate
n/a
Meas. Tech.
Binding Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
1.4±n/a nM
Comments
extracted
Citation
 Kinoyama, I; Miyazaki, T; Koganemaru, Y; Washio, T; Hamaguchi, W Nitrogenous-ring acylguanidine derivative US Patent  US8853242 Publication Date 10/7/2014 
Target
Name:
5-hydroxytryptamine receptor 5A
Synonyms:
5-HT-5 | 5-HT-5A | 5-hydroxytryptamine receptor 5 (5-HT5) | 5-hydroxytryptamine receptor 5A (5-HT5A) | 5HT5A_HUMAN | HTR5A | Serotonin (5-HT) receptor | Serotonin receptor 5A
Type:
Enzyme
Mol. Mass.:
40266.25
Organism:
Homo sapiens (Human)
Description:
P47898
Residue:
357
Sequence:
MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
  
Inhibitor
Name:
BDBM135783
Synonyms:
US8853242, 148
Type:
Small organic molecule
Emp. Form.:
C17H11F3N4O
Mol. Mass.:
344.2906
SMILES:
NC(N)=NC(=O)c1ccc2c(F)cnc(-c3c(F)cccc3F)c2c1 |(6,-.77,;4.67,,;4.67,1.54,;3.33,-.77,;2,,;2,1.54,;.67,-.77,;.67,-2.31,;-.67,-3.08,;-2,-2.31,;-3.33,-3.08,;-3.33,-4.62,;-4.67,-2.31,;-4.67,-.77,;-3.33,,;-3.33,1.54,;-4.67,2.31,;-6,1.54,;-4.67,3.85,;-3.33,4.62,;-2,3.85,;-2,2.31,;-.67,1.54,;-2,-.77,;-.67,,)|
Structure:
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