Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 5A
Ligand
BDBM135786
Substrate
n/a
Meas. Tech.
Binding Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
5.3±n/a nM
Comments
extracted
Citation
 Kinoyama, I; Miyazaki, T; Koganemaru, Y; Washio, T; Hamaguchi, W Nitrogenous-ring acylguanidine derivative US Patent  US8853242 Publication Date 10/7/2014 
Target
Name:
5-hydroxytryptamine receptor 5A
Synonyms:
5-HT-5 | 5-HT-5A | 5-hydroxytryptamine receptor 5 (5-HT5) | 5-hydroxytryptamine receptor 5A (5-HT5A) | 5HT5A_HUMAN | HTR5A | Serotonin (5-HT) receptor | Serotonin receptor 5A
Type:
Enzyme
Mol. Mass.:
40266.25
Organism:
Homo sapiens (Human)
Description:
P47898
Residue:
357
Sequence:
MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
  
Inhibitor
Name:
BDBM135786
Synonyms:
US8853242, 157
Type:
Small organic molecule
Emp. Form.:
C16H10F3N5O
Mol. Mass.:
345.2787
SMILES:
NC(N)=NC(=O)c1ccc2c(F)cnc(-c3c(F)cncc3F)c2c1 |(5.78,3.33,;4.23,3.33,;3.47,4.67,;3.47,2,;1.92,2,;1.15,3.33,;1.15,.67,;1.93,-.67,;1.15,-2,;-.38,-2,;-1.15,-3.33,;-.38,-4.67,;-2.69,-3.33,;-3.47,-2,;-2.69,-.67,;-3.47,.67,;-2.69,2,;-1.15,2,;-3.47,3.33,;-5,3.33,;-5.78,2,;-5.01,.67,;-5.78,-.67,;-1.15,-.67,;-.38,.67,)|
Structure:
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