Reaction Details Report a problem with these data
Target
Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase
Ligand
BDBM150808
Substrate
n/a
Meas. Tech.
Fluorogenic ACC Substrate Assay
pH
7.5±n/a
Ki
>1.000e+6±n/a nM
Comments
extracted
Citation
 Ariyakumaran, R; Pokrovskaya, V; Little, DJ; Howell, PL; Nitz, M Direct Staudinger-Phosphonite Reaction Provides Methylphosphonamidates as Inhibitors of CE4 De-N-acetylases. Chembiochem 16:1350-6 (2015) [PubMed]  Article 
Target
Name:
Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase
Synonyms:
PGAB_ECOLI | PNAG de-N-acetylase (PgaB) | pgaB | ycdR
Type:
Protein
Mol. Mass.:
77407.78
Organism:
Escherichia coli (Enterobacteria)
Description:
P75906
Residue:
672
Sequence:
MLRNGNKYLLMLVSIIMLTACISQSRTSFIPPQDRESLLAEQPWPHNGFVAISWHNVEDEAADQRFMSVRTSALREQFAWLRENGYQPVSIAQIREAHRGGKPLPEKAVVLTFDDGYQSFYTRVFPILQAFQWPAVWAPVGSWVDTPADKQVKFGDELVDREYFATWQQVREVARSRLVELASHTWNSHYGIQANATGSLLPVYVNRAYFTDHARYETAAEYRERIRLDAVKMTEYLRTKVEVNPHVFVWPYGEANGIAIEELKKLGYDMFFTLESGLANASQLDSIPRVLIANNPSLKEFAQQIITVQEKSPQRIMHIDLDYVYDENLQQMDRNIDVLIQRVKDMQISTVYLQAFADPDGDGLVKEVWFPNRLLPMKADIFSRVAWQLRTRSGVNIYAWMPVLSWDLDPTLTRVKYLPTGEKKAQIHPEQYHRLSPFDDRVRAQVGMLYEDLAGHAAFDGILFHDDALLSDYEDASAPAITAYQQAGFSGSLSEIRQNPEQFKQWARFKSRALTDFTLELSARVKAIRGPHIKTARNIFALPVIQPESEAWFAQNYADFLKSYDWTAIMAMPYLEGVAEKSADQWLIQLTNQIKNIPQAKDKSILELQAQNWQKNGQHQAISSQQLAHWMSLLQLNGVKNYGYYPDNFLHNQPEIDLIRPEFSTAWYPKND
  
Inhibitor
Name:
BDBM150808
Synonyms:
Sodium N-methylphosphate-1-O-methyl-6-O-benzyl-beta-D-glucosamine (15d)
Type:
Small organic molecule
Emp. Form.:
C15H23NNaO7P
Mol. Mass.:
383.3092
SMILES:
[Na+].CO[C@@H]1OC(COCc2ccccc2)[C@@H](O)C(O)[C@@H]1NP(C)([O-])=O |r|
Structure:
Search PDB for entries with ligand similarity: