Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 2
Ligand
BDBM150927
Substrate
n/a
Meas. Tech.
In Vitro Inhibition Assay
Temperature
310.15±n/a K
IC50
>10000±n/a nM
Comments
extracted
Citation
 Maeda, DY; Zebala, JA Pyrimidinecarboxamides as CXCR2 modulators US Patent  US8981106 Publication Date 3/17/2015 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM150927
Synonyms:
US8981106, 116
Type:
Small organic molecule
Emp. Form.:
C18H13FN2O3S
Mol. Mass.:
356.371
SMILES:
Fc1ccc(NC(=O)c2ccc(SCC(=O)c3ccco3)nc2)cc1
Structure:
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