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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM269504
Substrate
n/a
Meas. Tech.
[125I]DOI Radioligand Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
46.0±n/a nM
Comments
extracted
Citation
 Xiong, Y; Feichtinger, K; Ren, AS; Ullman, B Imidazo[1,2-a]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto US Patent  US9567327 Publication Date 2/14/2017 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM269504
Synonyms:
(4-(4-fluorophenethyl)piperazin-1- yl)(2-phenylimidazo[1,2-a]pyridin- yl)methanone | US10058549, 9
Type:
Small organic molecule
Emp. Form.:
C26H25FN4O
Mol. Mass.:
428.5013
SMILES:
Fc1ccc(CCN2CCN(CC2)C(=O)c2cccn3cc(nc23)-c2ccccc2)cc1
Structure:
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