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Target
Orexin receptor type 2
Ligand
BDBM154933
Substrate
n/a
Meas. Tech.
In Vitro Assay
Temperature
310.15±n/a K
IC50
3±n/a nM
Comments
extracted
Citation
 Boss, C; Brotschi, C; Gatfield, J; Gude, M; Heidmann, B; Sifferlen, T; Williams, JT Proline sulfonamide derivatives as orexin receptor antagonists US Patent  US9000029 Publication Date 4/7/2015 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM154933
Synonyms:
US9000029, 12
Type:
Small organic molecule
Emp. Form.:
C19H21ClN2O3S2
Mol. Mass.:
424.965
SMILES:
CSc1cccc(NC(=O)[C@@H]2CCCN2S(=O)(=O)c2ccc(C)c(Cl)c2)c1
Structure:
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