Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM161384
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5000±n/a
Temperature
277.1500±n/a K
IC50
130±n/a nM
Comments
extracted
Citation
 Patel, S; Mao, J; Liu, Q; Harrison, T; Duvadie, R; Chen, X; Zecri, F Cyclic ether DGAT1 inhibitorscyclic ether DGAT1 inhibitors US Patent  US9108956 Publication Date 8/18/2015 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
Diacylglycerol Acyltransferase (DGAT1) | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | ACAT-related gene product 1 | Diglyceride acyltransferase | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | DGAT1_HUMAN | DGAT1 | AGRP1 | DGAT
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Human
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM161384
Synonyms:
US9108956, 10 | US9108956, 9 | US9108956, 11 | US9108956, 8
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
OC(=O)CC1CCC(OC1)c1ccc(cc1)-c1ccc(Nc2nnc(o2)C2CCC2)cc1
Structure:
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