Reaction Details Report a problem with these data
Target
Leucine--tRNA ligase [A132I,E138V,K510A,I952T]
Ligand
BDBM163674
Substrate
n/a
Meas. Tech.
Isothermal Titration Calorimetry (ITC)
pH
8±0
Temperature
298.15±0 K
Kd
4.6e+4± 6e+3 nM
Citation
Zhao, H; Palencia, A; Seiradake, E; Ghaemi, Z; Cusack, S; Luthey-Schulten, Z; Martinis, S Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism. ACS Chem Biol 10:2277-85 (2015) [PubMed] Article
More Info.:
Target
Name:
Leucine--tRNA ligase [A132I,E138V,K510A,I952T]
Synonyms:
Leucyl-tRNA synthetase K510A mutant (K510A)
Type:
Protein
Mol. Mass.:
125339.73
Organism:
Candida albicans (Ascomycetes)
Description:
A0A1D8PS12[A132I,E138V,K510A,I952T]
Residue:
1097
Sequence:
MSGPVTFEKTFRRDALIDIEKKYQKVWAEEKVFEVDAPTFEECPIEDVEQVQEAHPKFFATMAYPYMNGVLHAGHAFTLSKVEFATGFQRMNGKRALFPLGFHCTGMPIKAAADKIKREVELFGSDFSKAPIDDEDAVESQQPAKTETKREDVTKFSSKKSKAAAKQGRAKFQYEIMMQLGIPREEVAKFANTDYWLEFFPPLCQKDVTAFGARVDWRRSMITTDANPYYDAFVRWQINRLRDVGKIKFGERYTIYSEKDGQACLDHDRQSGEGVGPQEYVGIKIRLTDVAPQAQELFKKENLDVKENKVYLVAATLRPETMYGQTCCFVSPKIDYGVFDAGNGDYFITTERAFKNMSFQNLTPKRGYYKPLFIINGKTLIGSRIDAPYAVNKNLRVLPMETVLATKGTGVVTCVPSDSPDDFVTTRDLANKPEYYGIEKDWVQTDIVPIVHTEKYGDKCAEFLVNDLKIQSPKDSVQLANAKELAYKEGFYNGTMLIGKYKGDKVEDAAPKVKQDLIDEGLAFVYNEPESQVISRSGDDCCVSLEDQWYIDYGEEAWLGEALECLKNMETYSKETRHGFEGVLAWMKNWAVTRKFGLGTKLPWDPQYLVESLSDSTVYMAYYTIDRFLHSDYYGKKAGKFDIKPEQMTDEVFDYIFTRRDDVETDIPKEQLKEMRREFEYFYPLDVRVSGKDLIPNHLTFFIYTHVALFPKRFWPRGVRANGHLLLNNAKMSKSTGNFMTLEQIIEKFGADASRIAMADAGDTVEDANFDEANANAAILRLTTLKDWCEEEVKNQDKLRTGDYDSFFDAAFENEMNDLIEKTYQQYTLSNYKQALKSGLFDFQIARDIYRESVNTTGIGMHKDLVLKYIEYQALMLAPIAPHFAEYLYREVLGKNGSVQTSKFPRASKPVSKAILDASEYVRSLTRSIREAEGQALKKKKGKSDVDGSKPTSLTVLVSNTFPEWQDNYIELVRELFEQNKLDDNNVIRQKVGKDMKRGMPYIHQIKTRLATEDADTVFNRKLTFDEIDTLKNVVEIVKNAPYSLKVEKLEILSFNNGETKGKNIISGEDNIELNFKGKIMENAVPGEPGIFIKNVE