Target
Orexin receptor type 2
Ligand
BDBM164112
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Temperature
313.15±n/a K
Ki
239±n/a nM
Comments
extracted
Citation
 Coate, HRDvorak, CALebold, TPPreville, CShireman, BT Substituted 7-azabicyles and their use as orexin receptor modulators US Patent  US9062078 Publication Date 6/23/2015 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM164112
Synonyms:
US9062078, 242 | US9475819, 242 | US9637496, 242 | US9695183, 242
Type:
Small organic molecule
Emp. Form.:
C21H20F3N7O2
Mol. Mass.:
459.4244
SMILES:
COc1cccc(c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 |TLB:17:15:13.12:10|
Structure:
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