Reaction Details
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Caspase-1
Ligand
BDBM50451094
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
6e+2± 3 nM
Comments
extracted
Citation
Kawarski, M; Hagerman, TK; Karver, CE Lazaroids U83836E and U74389G are potent, time-dependent inhibitors of caspase-1. Chem Biol Drug Des 86:1049-54 (2015) [PubMed] Article More Info.:
Target
Name:
Caspase-1
Synonyms:
CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Homo sapiens (Human)
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
Inhibitor
Name:
BDBM50451094
Synonyms:
Ascorbyl Palmitate | Ascorbyl palmitate (E5) | E304
Type:
Small organic molecule
Emp. Form.:
C22H38O7
Mol. Mass.:
414.5329
SMILES:
[H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)COC(=O)CCCCCCCCCCCCCCC |c:6|
Structure:
