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Target
Kappa-type opioid receptor
Ligand
BDBM173476
Substrate
n/a
Meas. Tech.
Radioligand Dose-Displacement Binding Assay
pH
7.4±n/a
Temperature
277.15±n/a K
Ki
165.12±37.15 nM
Comments
extracted
Citation
 Kyle, DJ Quarternized buprenorphine analogs US Patent  US9096606 Publication Date 8/4/2015 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM173476
Synonyms:
US9096606, 13
Type:
Small organic molecule
Emp. Form.:
C37H44NO4
Mol. Mass.:
566.7496
SMILES:
COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1ccc2ccccc2c1)C5 |r,TLB:28:27:18.14:10.9|
Structure:
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