Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 1 [T157A,D319N]
Ligand
BDBM176672
Substrate
n/a
Meas. Tech.
Fluorescence Quenching Assay
Kd
6400±300 nM
Citation
 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S Non-ATP dependent inhibitors of extracellular signal-regulated kinase (ERK) US Patent  US9115122 Publication Date 8/25/2015 
Target
Name:
Mitogen-activated protein kinase 1 [T157A,D319N]
Synonyms:
ERK2(T157A/D319N) | MK01_MOUSE | Mapk1 | Erk2 | Mapk | Prkm1
Type:
n/a
Mol. Mass.:
41248.65
Organism:
Mouse
Description:
P63085[T157A,D319N]
Residue:
358
Sequence:
MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNATCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSNEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM176672
Synonyms:
US9115122, 76
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CCOc1ccc(\C=C2/SC(=S)N(CCN)C2=O)cc1
Structure:
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