Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 14
Ligand
BDBM176672
Substrate
n/a
Meas. Tech.
Fluorescence Quenching Assay
Kd
7000±900 nM
Citation
 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S Non-ATP dependent inhibitors of extracellular signal-regulated kinase (ERK) US Patent  US9115122 Publication Date 8/25/2015 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
Mitogen-activated protein kinase p38 alpha | MAP Kinase p38 alpha | Mitogen-activated protein kinase 14 | MK14_MOUSE | Mapk14 | Crk1 | Csbp1 | Csbp2 | MAP kinase p38
Type:
Enzyme
Mol. Mass.:
41281.22
Organism:
Mouse
Description:
The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli.. Soluble murine p38R was extracted from cell pellets and purified using ion-exchange chromatography.
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM176672
Synonyms:
US9115122, 76
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CCOc1ccc(\C=C2/SC(=S)N(CCN)C2=O)cc1
Structure:
Search PDB for entries with ligand similarity: