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Target
Alpha-1D adrenergic receptor
Ligand
BDBM186935
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
pH
7.4±n/a
Ki
4181±n/a nM
Comments
extracted
Citation
 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K Morpholino compounds, uses and methods US Patent  US9079895 Publication Date 7/14/2015 
Target
Name:
Alpha-1D adrenergic receptor
Synonyms:
ADA1D_MOUSE | Adra1a | Adra1d | Alpha-1 adrenergic receptor | Gpcr8 | adrenergic Alpha2
Type:
Enzyme
Mol. Mass.:
59890.14
Organism:
Mus musculus (Mouse)
Description:
P97714
Residue:
562
Sequence:
MTFRDILSVTFEGPRASSSTGGSGAGGGAGTVGPEGPAVGGVPGATGGSAVVGTGSGEDNQSSTAEAGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWPFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGNPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWPSLRPPLASLDRRPALRLCPQPAHRTPRGSPSPHCTPRPGLRRHAGGAGFGLRPSKASLRLREWRLLGPLQRPTTQLRAKVSSLSHKFRSGGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDLSNLRETDI
  
Inhibitor
Name:
BDBM186935
Synonyms:
US9079895, 23s
Type:
Small organic molecule
Emp. Form.:
C21H25ClN2O2
Mol. Mass.:
372.888
SMILES:
Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc34)CCO2)c1 |r|
Structure:
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