Reaction Details Report a problem with these data
Target
Serum paraoxonase/arylesterase 1
Ligand
BDBM50127140
Substrate
n/a
Meas. Tech.
Paraoxonase Activity Assay
pH
10.5000±n/a
Ki
1.31e+5± 7.1e+4 nM
IC50
2.26e+5±n/a nM
Comments
extracted
Citation
 Alim, Z; Beydemir, S Some Anticancer Agents Act on Human Serum Paraoxonase-1 to Reduce Its Activity. Chem Biol Drug Des 88:188-96 (2016) [PubMed]  Article 
Target
Name:
Serum paraoxonase/arylesterase 1
Synonyms:
K-45 | Paraoxonase (hPON1) | A-esterase 1 | Aromatic esterase 1 | Serum paraoxonase 1 (PON1) | Serum aryldialkylphosphatase 1 | Paraoxonase 1 (PON1) | PON 1 | Paraoxonase (PON1) | PON1_HUMAN | PON1 | PON
Type:
Enzyme
Mol. Mass.:
39719.73
Organism:
Human
Description:
P27169
Residue:
355
Sequence:
MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFTDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
  
Inhibitor
Name:
BDBM50127140
Synonyms:
4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside) | 4-demethylepipodophyllotoxin beta-D-ethylideneglucoside | 9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one | VP-16 | CHEMBL44657 | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside | etoposide | (-)-etoposide | TRANS-ETOPOSIDE | Etoposide (ET)
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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