Reaction Details Report a problem with these data
Target
Kinesin-like protein KIF11 [15-368]
Ligand
BDBM189360
Substrate
n/a
Meas. Tech.
ADP Hunter Plus Assay
pH
7.0000±n/a
Temperature
298.1500±n/a K
IC50
7.89e+4±n/a nM
Comments
extracted
Citation
 Zhang, W; Zhai, L; Lu, W; Boohaker, RJ; Padmalayam, I; Li, Y Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening. Chem Biol Drug Des 88:178-87 (2016) [PubMed]  Article 
Target
Name:
Kinesin-like protein KIF11 [15-368]
Synonyms:
KIF11_HUMAN | KIF11 | EG5 | KNSL1 | TRIP5 | Mitotic kinesin Eg5 (Eg5)
Type:
Protein
Mol. Mass.:
39484.97
Organism:
Human
Description:
Eg5 motor domain (15-368aa)
Residue:
354
Sequence:
KGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQK
  
Inhibitor
Name:
BDBM189360
Synonyms:
SRI35565
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
FC(F)(F)c1ccc(Nc2ncnc3[nH]ncc23)cc1
Structure:
Search PDB for entries with ligand similarity: