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Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM190273
Substrate
n/a
Meas. Tech.
SEAP Activity Assay
Temperature
310.1500±n/a K
EC50
1960±n/a nM
Comments
extracted
Citation
 Barrett, SD; Ciske, FL; Colombo, JM; Endres, GW; Germain, BD; Kornilov, A; Kramer, JB; Uzieblo, A; Maxey, KM Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions US Patent  US9180116B2 Publication Date 11/10/2015 
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PGE receptor EP2 subtype | Prostaglandin E2 | Prostanoid EP2 Receptor | PE2R2_HUMAN | PTGER2 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP4 subtype
Type:
Enzyme
Mol. Mass.:
39775.71
Organism:
Human
Description:
P43116
Residue:
358
Sequence:
MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
  
Inhibitor
Name:
BDBM190273
Synonyms:
US9180116, 21C
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
395.19
SMILES:
CCCCC[C@H](O)\C=C\[C@H]1CC(F)(F)C(=O)N1CCc1ccc(cc1)C(O)=O
Structure:
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