Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM203253
Substrate
n/a
Meas. Tech.
In Vitro Assay: Intracellular Calcium Measurements
Temperature
310.15±n/a K
IC50
31±n/a nM
Comments
extracted
Citation
 Aissaoui, H; Boss, C; Brotschi, C; Heidmann, B; Sifferlen, T; Williams, JT Lactam derivatives useful as orexin receptor antagonists US Patent  US9242970 Publication Date 1/26/2016 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM203253
Synonyms:
US9242970, 436
Type:
Small organic molecule
Emp. Form.:
C20H18ClF4NO3
Mol. Mass.:
431.808
SMILES:
CCOc1cccc(Cl)c1[C@@H]1C[C@H](F)C(=O)N1Cc1ccc(OC(F)(F)F)cc1 |o1:10,12|
Structure:
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