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Target
Cannabinoid receptor 1
Ligand
BDBM208280
Substrate
n/a
Meas. Tech.
cAMP Assay
EC50
29±n/a nM
Citation
 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C Quinoline derivatives useful as CB-1 inverse agonists US Patent  US9266835 Publication Date 2/23/2016 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM208280
Synonyms:
US9266835, 51
Type:
Small organic molecule
Emp. Form.:
C29H27ClF3N3O5S
Mol. Mass.:
622.055
SMILES:
COc1ccc(cc1)C(O)(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1
Structure:
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