Reaction Details Report a problem with these data
Target
Synaptic vesicular amine transporter [V41A]
Ligand
BDBM50017712
Substrate
n/a
Meas. Tech.
[3H]Serotonin Uptake Assay
pH
8.5000±n/a
IC50
1.3±1.5 nM
Comments
extracted
Citation
 Ugolev, Y; Segal, T; Yaffe, D; Gros, Y; Schuldiner, S Identification of conformationally sensitive residues essential for inhibition of vesicular monoamine transport by the noncompetitive inhibitor tetrabenazine. J Biol Chem 288:32160-71 (2013) [PubMed]  Article 
Target
Name:
Synaptic vesicular amine transporter [V41A]
Synonyms:
VMAT2_RAT | Slc18a2 | Svat | Vmat2 | Vesicular monoamine transporter 2 (VMAT V41A)
Type:
Protein
Mol. Mass.:
55661.53
Organism:
Rat
Description:
Rat VMAT2 V41A mutant
Residue:
515
Sequence:
MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVAPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
  
Inhibitor
Name:
BDBM50017712
Synonyms:
Apoplon | 3,4,5-trimethoxybenzoyl methyl reserpate | Reserpin | (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester | methyl (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylate | (-)-reserpine | CHEMBL772 | Serpalan | RESERPINE | NCGC00091250 | cid_5770
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1ccc2c(c1)[nH]c3c2CCN4[C@@H]3C[C@H]5[C@@H](C4)C[C@H]([C@@H]([C@H]5C(=O)OC)OC)OC(=O)c6cc(c(c(c6)OC)OC)OC
Structure:
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