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Target
Kappa-type opioid receptor [H291F]
Ligand
BDBM214798
Substrate
n/a
Meas. Tech.
cAMP Inhibition Assay
pH
7.4000±n/a
EC50
81±7 nM
Comments
extracted
Citation
 Vardy, E; Mosier, PD; Frankowski, KJ; Wu, H; Katritch, V; Westkaemper, RB; Aubé, J; Stevens, RC; Roth, BL Chemotype-selective modes of action of ¿-opioid receptor agonists. J Biol Chem 288:34470-83 (2013) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor [H291F]
Synonyms:
Kappa opioid receptor (KOR H291F) | OPRK_HUMAN | OPRK1 | OPRK
Type:
Protein
Mol. Mass.:
42658.29
Organism:
Human
Description:
Human KOR with H291F mutation
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIFIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM214798
Synonyms:
YGGFLRRIRPKLK | Dynorphin A (1-17)
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: