Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q]
Ligand
BDBM50004656
Substrate
n/a
Meas. Tech.
[35S]GTPγS Binding/Immunoprecipitation Assay
Ki
3.32e+4± 7.0e+3 nM
Citation
 Hu, J; Hu, K; Liu, T; Stern, MK; Mistry, R; Challiss, RA; Costanzi, S; Wess, J Novel structural and functional insights into M3 muscarinic receptor dimer/oligomer formation. J Biol Chem 288:34777-90 (2013) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q]
Synonyms:
ACM3_RAT | Chrm3 | Chrm-3 | M3 muscarinic receptor (M3'(3C)-Xa)
Type:
Protein
Mol. Mass.:
46046.63
Organism:
Rat
Description:
Modified rat M3R Δ274-469 lacking N-glycosylation sites (N6Q, N15Q, N41Q, N48Q, N52Q) and contains triple factor Xa site (IEGR)3 within i3 loop
Residue:
405
Sequence:
MTLHSQSTTSPLFPQISSSWVHSPSEAGLPLGTVTQLGSYQISQETGQFSSQDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEIEGRIEGRIEGRTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
  
Inhibitor
Name:
BDBM50004656
Synonyms:
(2-Hydroxyethyl)trimethyl ammonium chloride carbamate | Choline chlorine carbamate | 2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminum chloride | (2-Carbamoyloxyethyl)trimethylammonium chloride | Karbachol | Carbachol chloride | (2-Hydroxyethyl)trimethylammonium chloride carbamate | (carbachol)(2-Carbamoyloxy-ethyl)-trimethyl-ammonium | CHEMBL14 | CARBASTAT | Karbamoylcholin chlorid | 2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminium chloride | 2-(carbamoyloxy)-N,N,N-trimethylethanaminium | MIOSTAT | Choline carbamate chloride | CARBACHOL | Choline chloride, carbamate | (2-Carbamoyloxy-ethyl)-trimethyl-ammonium | Carbamylcholine | 2-(carbamoyloxy)-N,N,N-trimethylethanaminium chloride
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
C[N+](C)(C)CCOC(=O)N
Structure:
Search PDB for entries with ligand similarity: