Reaction Details Report a problem with these data
Target
Ephrin type-A receptor 4 [29-209]
Ligand
BDBM223300
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
pH
7.2000±n/a
Temperature
298.1500±n/a K
Ki
2140±n/a nM
Comments
extracted
Citation
 Wu, B; De, SK; Kulinich, A; Salem, AF; Koeppen, J; Wang, R; Barile, E; Wang, S; Zhang, D; Ethell, I; Pellecchia, M Potent and Selective EphA4 Agonists for the Treatment of ALS. Cell Chem Biol 24:293-305 (2017) [PubMed]  Article 
Target
Name:
Ephrin type-A receptor 4 [29-209]
Synonyms:
EPHA4_HUMAN | EPHA4 | HEK8 | SEK | TYRO1 | Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)
Type:
Protein
Mol. Mass.:
20850.44
Organism:
Human
Description:
Human EphA4-LBD (29-209 aa)
Residue:
181
Sequence:
NEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVR
  
Inhibitor
Name:
BDBM223300
Synonyms:
EphA4-LBC inhibitor, Compound 22
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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