Reaction Details Report a problem with these data
Target
Ephrin type-A receptor 4 [29-209]
Ligand
BDBM223306
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
pH
7.2±n/a
Temperature
298.15±n/a K
Ki
7670±n/a nM
Comments
extracted
Citation
 Wu, B; De, SK; Kulinich, A; Salem, AF; Koeppen, J; Wang, R; Barile, E; Wang, S; Zhang, D; Ethell, I; Pellecchia, M Potent and Selective EphA4 Agonists for the Treatment of ALS. Cell Chem Biol 24:293-305 (2017) [PubMed]  Article 
Target
Name:
Ephrin type-A receptor 4 [29-209]
Synonyms:
EPHA4 | EPHA4_HUMAN | Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD) | HEK8 | SEK | TYRO1
Type:
Protein
Mol. Mass.:
20850.44
Organism:
Human
Description:
Human EphA4-LBD (29-209 aa)
Residue:
181
Sequence:
NEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVR
  
Inhibitor
Name:
BDBM223306
Synonyms:
123C12
Type:
Small organic molecule
Emp. Form.:
C44H46ClN7O5
Mol. Mass.:
788.333
SMILES:
NCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCCc1cccc2ccccc12 |r|
Structure:
Search PDB for entries with ligand similarity: