Reaction Details Report a problem with these data
Target
Ephrin type-A receptor 4 [29-209,I159A]
Ligand
BDBM223311
Substrate
n/a
Meas. Tech.
Isothermal Titration Calorimetry (ITC)
pH
6.5000±0.0000
Temperature
300.1500±0.0000 K
Kd
290±20 nM
Citation
 Wu, B; De, SK; Kulinich, A; Salem, AF; Koeppen, J; Wang, R; Barile, E; Wang, S; Zhang, D; Ethell, I; Pellecchia, M Potent and Selective EphA4 Agonists for the Treatment of ALS. Cell Chem Biol 24:293-305 (2017) [PubMed]  Article 
Target
Name:
Ephrin type-A receptor 4 [29-209,I159A]
Synonyms:
EPHA4_HUMAN | EPHA4 | HEK8 | SEK | TYRO1 | Ephrin type-A receptor 4 ligand binding domain (I159A-EphA4-LBD)
Type:
Protein
Mol. Mass.:
20808.36
Organism:
Human
Description:
Human EphA4-LBD I159A mutant
Residue:
181
Sequence:
NEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDAGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVR
  
Inhibitor
Name:
BDBM223311
Synonyms:
123C4
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1ccc2[nH]cc(CCNC(=O)[C@H](Cc3ccncc3)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC(=O)[C@H](Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c2c1 |r|
Structure:
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